Clostridium Difficile Glutamate Dehydrogenase (GDH) da Toxin A/B

Clostridium difficile (CD) wani nau'in bacillus ne na anaerobic gram-positive, wanda shine tsire-tsire na yau da kullun a jikin mutum. Sauran flora za a hana su girma saboda maganin rigakafi da ake amfani da su a cikin manyan allurai, kuma CD yana haifuwa a cikin jikin mutum da yawa. CD ya kasu kashi biyu masu samar da guba da kuma wadanda ba su da guba. Duk nau'ikan CD suna samar da glutamate dehydrogenase (GDH) lokacin da suka haihu, kuma nau'ikan masu guba ne kawai. Abubuwan da ke haifar da toxin na iya haifar da guba guda biyu, A da B. Toxin A shine enterotoxin, wanda zai iya haifar da kumburi na bangon hanji, shigar da kwayar halitta, ƙara haɓakar bangon hanji, zubar jini da necrosis. Toxin B shine cytotoxin, wanda ke lalata cytoskeleton, yana haifar da pyknosis da necrosis, kuma kai tsaye yana lalata ƙwayoyin parietal na hanji, yana haifar da gudawa da pseudomembranous colitis.