Clostridium Difficile Glutamate Dehydrogenase (GDH) da Toxin A/B

Clostridium difficile (CD) wani nau'in bacillus ne mai kama da anaerobic gram-positive, wanda wani nau'in flora ne na yau da kullun a jikin ɗan adam. Sauran flora za a hana su ninka saboda maganin rigakafi da ake amfani da su a adadi mai yawa, kuma CD yana hayayyafa a jikin ɗan adam a adadi mai yawa. CD yana raba zuwa nau'ikan da ke samar da guba da waɗanda ba sa haifar da guba. Duk nau'ikan CD suna samar da glutamate dehydrogenase (GDH) lokacin da suka hayayyafa, kuma nau'ikan da ke haifar da guba ne kawai ke haifar da cututtuka. Nau'ikan da ke samar da guba na iya samar da guba guda biyu, A da B. Toxin A enterotoxin ne, wanda zai iya haifar da kumburi a bangon hanji, shigar ƙwayoyin halitta, ƙaruwar shiga bangon hanji, zubar jini da necrosis. Toxin B wani cytotoxin ne, wanda ke lalata cytoskeleton, yana haifar da pyknosis na ƙwayoyin halitta da necrosis, kuma yana lalata ƙwayoyin parietal na hanji kai tsaye, wanda ke haifar da gudawa da cutar pseudomembranous.