Acid Nucleic Polymorphic na Halittar MTHFR

Folic acid wani sinadari ne mai narkewa cikin ruwa wanda ke da matukar muhimmanci a cikin hanyoyin rayuwa na jiki. A cikin 'yan shekarun nan, adadi mai yawa na bincike sun tabbatar da cewa, maye gurbin kwayar halittar enzyme ta folate metabolizing MTHFR zai haifar da karancin folic acid a jiki, kuma lalacewar da ake samu ta karancin folic acid a cikin manya na iya haifar da karancin megaloblastic anemia, lalacewar jijiyoyin jini, da sauransu. Rashin Folic acid a cikin mata masu juna biyu ba zai iya biyan bukatun kansu da tayin ba, wanda zai iya haifar da lahani a cikin bututun jijiyoyi, anencephaly, haihuwa a mace, da kuma zubar da ciki. Matakan folate na jini suna shafar sakamakon 5,10-methylenetetrahydrofolate reductase (MTHFR). Sauye-sauyen 677C>T da 1298A>C a cikin kwayar halittar MTHFR suna haifar da canza alanine zuwa valine da glutamic acid, bi da bi, wanda ke haifar da raguwar ayyukan MTHFR kuma sakamakon haka rage amfani da folic acid.