Tarin Fuka na Mycobacterium Juriyar Nucleic Acid da Rifampicin

Tarin fuka na Mycobacterium, ba da daɗewa ba kamar Tubercle bacillus, TB, shine ƙwayar cuta mai haifar da tarin fuka. A halin yanzu, magungunan rigakafin tarin fuka na farko da ake amfani da su sun haɗa da isoniazid, rifampicin da hexambutol, da sauransu. Magungunan rigakafin tarin fuka na biyu sun haɗa da fluoroquinolones, amikacin da kanamycin, da sauransu. Sabbin magungunan da aka haɓaka sune linezolid, bedaquiline da delamani, da sauransu. Duk da haka, saboda rashin amfani da magungunan rigakafin tarin fuka daidai ba da kuma halayen tsarin bangon tantanin halitta na tarin fuka na mycobacterium, tarin fuka na mycobacterium yana haɓaka juriya ga magunguna ga magungunan rigakafin tarin fuka, wanda ke kawo ƙalubale masu tsanani ga rigakafi da maganin tarin fuka.

An yi amfani da Rifampicin sosai wajen magance masu fama da tarin fuka ta huhu tun daga ƙarshen shekarun 1970, kuma yana da tasiri mai mahimmanci. Ita ce zaɓi na farko don rage maganin chemotherapy ga masu fama da tarin fuka ta huhu. Juriyar Rifampicin galibi tana faruwa ne sakamakon maye gurbi na kwayar halittar rpoB. Duk da cewa sabbin magungunan hana tarin fuka suna fitowa koyaushe, kuma ingancin asibiti na masu fama da tarin fuka ta huhu shi ma ya ci gaba da inganta, har yanzu akwai ƙarancin magungunan hana tarin fuka, kuma abin da ke faruwa na amfani da magunguna marasa hankali a asibiti yana da yawa. Babu shakka, tarin fuka na Mycobacterium a cikin marasa lafiya da tarin fuka ta huhu ba za a iya kashe su gaba ɗaya cikin lokaci ba, wanda daga ƙarshe ke haifar da matakan juriya ga magunguna daban-daban a jikin majiyyaci, yana tsawaita lokacin cutar, kuma yana ƙara haɗarin mutuwar majiyyaci.