Samfurin-zuwa-Amsa Cikakkun-kai-kai C. Gano Cutar Kwayar cuta

Me ke kawo cutar C. Diff?

C.Diff kamuwa da cuta yana faruwa ne ta hanyar kwayoyin cuta da aka sani daClostridioides difficile (C. difficile), wanda yawanci yana zama mara lahani a cikin hanji. Duk da haka, lokacin da ma'aunin ƙwayoyin cuta na hanji ya rikice, sau da yawa amfani da ƙwayoyin rigakafi masu yawa, C. difficile zai iya girma da yawa kuma ya haifar da guba, yana haifar da kamuwa da cuta.

Wannan kwayar cutar tana wanzu a cikin dukamai gubada nau'ikan da ba su da guba, amma kawai nau'in guba mai guba (dafi A da B) suna haifar da cututtuka. Suna haifar da kumburi ta hanyar rushe ƙwayoyin epithelial na hanji. Toxin A shine da farko enterotoxin wanda ke lalata rufin hanji, haɓaka haɓakawa, da jawo ƙwayoyin rigakafi waɗanda ke sakin cytokines masu kumburi. Toxin B, cytotoxin mafi ƙarfi, yana kaiwa ga cytoskeleton actin na sel, wanda ke haifar da zagaye tantanin halitta, cirewa, da kuma mutuwa ta ƙarshe. Tare, waɗannan gubobi suna haifar da lalacewar nama da kuma amsawar rigakafi mai ƙarfi, wanda ke bayyana kamar colitis, zawo, kuma a lokuta masu tsanani, pseudomembranous colitis-mai tsanani kumburi na hanji.

Ta yayaC. Diffyaɗa?

C.Diff yana yaduwa cikin sauƙi. Yana samuwa a asibitoci, sau da yawa ana samun su a cikin ICUs, a hannun ma'aikatan asibiti, a kan benaye na asibiti da kuma hannaye, a kan thermometers na lantarki, da sauran kayan aikin likita ...

Abubuwan Haɗari ga C. Diff Infection

• ●Kwanciyar asibiti na dogon lokaci;

• ●Maganin rigakafi;

• ●Magungunan cutar sankara;

• ●Recent tiyata (hannun ciki, na ciki kewaye, hanji tiyata);

• ●Naso-na ciki abinci mai gina jiki;

• ●Kafin C. diff kamuwa da cuta;

Alamomin cutar C. Diff

C. Diff kamuwa da cuta na iya zama mara dadi. Yawancin mutane suna ci gaba da zawo da rashin jin daɗi a cikin ciki. Alamomin da aka fi sani sune: zawo, ciwon ciki, tashin zuciya, rashin ci, zazzabi.

Yayin da C. Diff kamuwa da cuta ya zama mai tsanani, za a sami ci gaban wani nau'i mai rikitarwa na C. diff da aka sani da colitis, pseudomembranous enteritis har ma da mutuwa.

Bincikena C. Diff Infection

Al'adun Kwayoyin cuta:Mai hankali amma yana ɗaukar lokaci (2-5days), ba zai iya bambanta nau'in guba da marasa guba ba;

Al'adar Guba:yana gano nau'ikan guba masu guba waɗanda ke haifar da cuta amma suna ɗaukar lokaci (3-5days) kuma basu da hankali;

Gano GDH:sauri (1-2hrs) kuma mai tsada, mai matukar damuwa amma ba zai iya bambanta nau'ikan guba da marasa guba ba;

Binciken Neutralization Cell Cytotoxicity (CCNA): yana gano guba A da B tare da babban hankali amma yana cin lokaci (2-3days), kuma yana buƙatar wurare na musamman da ma'aikata masu horarwa;

Toxin A/B ELISA: Gwaji mai sauƙi da sauri (1-2hrs) tare da ƙananan hankali da rashin kuskuren ƙarya akai-akai;

Gwajin Ƙarfafa Acid Nucleic (NAATs): Rapid (1-3hrs) kuma mai matukar damuwa & takamaiman, gano kwayoyin halittar da ke da alhakin samar da guba;

Bugu da ƙari, gwaje-gwajen hoto don bincika hanji, kamar CT scans da X-ray, ana iya amfani da su don taimakawa wajen gano cutar C. diff da rikitarwa na C. diff, kamar colitis.

Maganin C. Diff infection

Akwai zaɓuɓɓukan magani da yawa donC. Diff kamuwa da cuta. A ƙasa akwai mafi kyawun zaɓuɓɓuka:

• ●Ana amfani da maganin rigakafi na baka kamar vancomycin, metronidazole ko firaxomicin yayin da maganin zai iya wucewa ta tsarin narkewa kuma ya isa ga hanji inda kwayoyin C. diff suke zama.

• ●Ana iya amfani da metronidazole na cikin jijiya don magani idan kamuwa da cutar C. diff yayi tsanani.

• ●Ƙwayoyin ƙwayoyin cuta na fecal microbiota sun nuna tasiri wajen magance cututtuka masu yawa na C. diff da cututtuka masu tsanani na C. diff waɗanda ba sa amsa maganin rigakafi.

• ●Tiyata na iya zama dole don lokuta masu tsanani.

Maganin bincike daga MMT

Dangane da buƙatar gaggawa, daidaitaccen ganewar C. difficile, muna gabatar da sabon kayan aikin mu na Nucleic Acid Detection Kit don Clostridium difficile toxin A / B gene, ƙarfafa masu sana'a na kiwon lafiya don yin farkon ganewar asali da kuma tallafawa yaki da cututtuka na asibiti.

图片链接：

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  ●Babban Hankali: Yana gano ƙasa kaɗan200 CFU/ml,;

• 
  
  ●Madaidaicin Niyya: Daidai gano C. difficile toxin A/B gene, rage girman abubuwan karya;

• 
  
  ●Gano Cutar Kai tsaye: Yana amfani da gwajin nucleic acid don gano kwayoyin halitta masu guba kai tsaye, yana kafa ma'auni na zinariya don bincike.

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  ●Cikakken jituwa dakayan aikin PCR na yau da kullun suna magance ƙarin labs;

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