A cewar sabon rahoton cutar kansa na duniya, ciwon daji na huhu ya ci gaba da zama farkon sanadin mutuwar masu fama da cutar kansa a duniya, wanda ya kai kashi 18.7% na duk irin wannan mace-macen a shekarar 2022. Mafi yawan wadanda suka kamu da cutar sune wadanda ba kananan yara ba (NSCLC). Yayin da dogaron tarihi akan chemotherapy don cututtukan da suka ci gaba yana ba da fa'ida mai iyaka, tsarin ya canza asali.
Gano manyan alamomin halittu, irin su EGFR, ALK, da ROS1, ya kawo sauyi a jiyya, inda ya motsa shi daga tsarin da ya dace da kowane tsari zuwa madaidaicin dabarar da ke da alaƙa da keɓantattun ƙwayoyin ƙwayoyin cuta na ciwon daji na kowane mai haƙuri.
Duk da haka, nasarar waɗannan jiyya na juyin juya hali gaba ɗaya ya dogara ne akan ingantacciyar gwajin kwayoyin halitta don gano maƙasudin madaidaicin majinyaci.
Mahimman Bayanan Halitta: EGFR, ALK, ROS1, da KRAS
Ma'aikatan halitta guda huɗu sun tsaya a matsayin ginshiƙai a cikin ƙwayar ƙwayar cuta ta NSCLC, suna jagorantar yanke shawara na jiyya na farko:
-EGFR:Mafi yaɗuwar maye gurbi, musamman a Asiya, mata, da waɗanda ba shan taba ba. EGFR tyrosine kinase inhibitors (TKIs) kamar Osimertinib sun inganta sakamakon haƙuri sosai.
-ALK:"Maye gurbin lu'u-lu'u," yana samuwa a cikin 5-8% na lokuta na NSCLC. ALK fusion-tabbatacce marasa lafiya sukan amsa da gaske ga masu hana ALK, suna samun rayuwa na dogon lokaci.
-ROS1:Rarraba kamanceceniya na tsari tare da ALK, wannan “rare gem” yana faruwa a cikin 1-2% na marasa lafiya na NSCLC. Ana samun ingantattun hanyoyin kwantar da hankali, yana mai da gano shi mai mahimmanci.
-KRAS:A tarihi ana la'akari da "marasa lafiya," maye gurbin KRAS na kowa. Amincewar kwanan nan na masu hana masu hana KRAS G12C sun canza wannan alamar halitta daga alamar tsinkaya zuwa maƙasudin aiki, juyin juya halin kulawa ga wannan rukunin mara lafiya.
Portfolio na MMT: Injiniya don Amincewar Ganewa
Don saduwa da buƙatu na gaggawa na ainihin gano alamar biomarker, MMT yana ba da fayil na CE-IVD alama na ainihin-lokaci.PCR kayan ganowa, kowanne an ƙera shi tare da fasaha mai mahimmanci don tabbatar da amincewar bincike.
1. Kit ɗin Gano maye gurbi na EGFR
-Ingantattun Fasahar ARMS:Masu haɓaka mallakar mallaka suna ƙara haɓaka takamaiman maye gurbi.
-Inganta Enzymatic:Ƙuntatawar endonucleases na narkar da asalin halittar daji na nau'in daji, haɓaka jerin mutant da haɓaka ƙuduri.
-Toshe Zazzabi:Wani takamaiman matakin zafi yana rage ƙayyadaddun firam ɗin da ba na musamman ba, yana ƙara rage girman nau'in daji.
-Mabuɗin Amfani:Hankali mara misaltuwa zuwa1%mutant allele mita, ingantacciyar daidaito tare da sarrafawa na ciki da enzyme UNG, da saurin juyawa na kusanMinti 120.
- Mai jituwa daduka nama da samfurin biopsy na ruwa.
- MMT EML4-ALK Fusion Gane Kit
- Babban Hankali:Yana gano daidaitattun maye gurbi tare da ƙaramin iyaka na gano kwafi/ amsawa 20.
-Kyakkyawan Daidaito:Haɗa ƙa'idodi na ciki don sarrafa tsari da enzyme na UNG don hana gurɓatawa mai ɗaukar nauyi, yadda ya kamata don guje wa halayen ƙarya da rashin ƙarfi.
-Sauƙi & Sauƙi:Yana fasalta ingantaccen aiki, rufaffiyar bututu da aka kammala cikin kusan mintuna 120.
-Daidaituwar Kayan aiki:Daidaitacce zuwa iri-iri na gama-garikayan aikin PCR na ainihi, bayar da sassauci ga kowane saitin dakin gwaje-gwaje.
- MMT ROS1 Fusion Gane Kit
Babban Hankali:Yana nuna kyakkyawan aiki ta hanyar ganowa ƙasa da kwafi 20/maganin maƙasudin haɗaka.
Kyakkyawan Daidaito:Yin amfani da sarrafa ingancin ciki da UNG enzyme yana tabbatar da amincin kowane sakamako, yana rage haɗarin yin rahoton kurakurai.
Sauƙi & Sauƙi:A matsayin tsarin rufaffiyar bututu, baya buƙatar hadaddun matakan haɓakawa. Ana samun sakamako mai ma'ana da abin dogaro a cikin kusan mintuna 120.
Daidaituwar Kayan aiki:An ƙera shi don dacewa mai faɗi tare da kewayon injunan PCR na yau da kullun, yana sauƙaƙe haɗawa cikin ayyukan laburaren da ke akwai.
- Kit ɗin Gano maye gurbi na MMT KRAS
- Ingantattun fasahar ARMS, ƙarfafa ta Enzymatic Enrichment and Temperature Blocking.
- Inganta Enzymatic:Yana amfani da ƙuntatawa endonucleases don zaɓar nau'in nau'in nau'in nau'in halitta na daji, don haka yana haɓaka jerin halittu da haɓaka ƙudurin ganowa.
-Toshe Zazzabi:Gabatar da takamaiman matakin zafin jiki don haifar da rashin daidaituwa tsakanin ƙayyadaddun ƙayyadaddun mutant-mutant da samfuran nau'in daji, ƙara rage bango da haɓaka ƙayyadaddun bayanai.
- Babban Hankali:Ya sami ƙwarewar ganowa na 1% don mutant alleles, yana tabbatar da gano ƙananan maye gurbi.
-Kyakkyawan Daidaito:Haɗe-haɗen ƙa'idodi na ciki da kariya ta enzyme UNG daga ingantaccen sakamako na ƙarya.
-Cikakken Panel:An daidaita shi da kyau don sauƙaƙe gano nau'ikan maye gurbi guda takwas na KRAS a cikin bututun amsawa guda biyu kawai.
- Sauƙi & Sauƙi:Yana ba da tabbataccen sakamako kuma abin dogaro a cikin kusan mintuna 120.
- Daidaituwar Kayan aiki:Yana daidaitawa da kayan aikin PCR daban-daban, yana ba da dama ga dakunan gwaje-gwaje na asibiti.
Me yasa Zabi Maganin MMT NSCLC?
M: Cikakken ɗakin kwana don mafi mahimmancin alamun NSCLC guda huɗu.
Mafi Girman Fasaha: Haɓakawa na Mallaka (Ingantaccen Enzymatic, Kashe Zazzabi) yana tabbatar da ƙayyadaddun ƙayyadaddun ƙayyadaddun bayanai da azanci a inda ya fi dacewa.
Mai sauri & Inganci: Uniform ~ yarjejeniya na mintuna 120 a cikin fayil ɗin yana haɓaka lokaci-zuwa-jiyya.
M & Mai yiwuwa: Mai jituwa tare da nau'ikan samfuri iri-iri da kayan aikin PCR na yau da kullun, rage girman shingen aiwatarwa.
Kammalawa
A zamanin madaidaicin ilimin oncology, binciken ƙwayoyin cuta shine kamfas wanda ke jagorantar kewayawa na warkewa. Na'urorin ganowa na ci gaba na MMT suna ƙarfafa likitocin su yi taswirar gaba gaɗi taswirar yanayin halittar NSCLC na majiyyaci, buɗe yuwuwar ceton rai na hanyoyin da aka yi niyya.
Contact to learn more: marketing@mmtest.com
Lokacin aikawa: Nuwamba-05-2025