Maye gurbin maki a cikin kwayoyin halittar KRAS suna da hannu a cikin kewayon ciwace-ciwacen mutum, tare da adadin maye gurbi na kusan 17%-25% a fadin nau'in ƙari, 15% – 30% a cikin ciwon huhu, da 20% – 50% a cikin ciwon daji na colorectal. Waɗannan maye gurbi suna haifar da juriya na jiyya da ci gaban ƙari ta hanyar maɓalli mai mahimmanci: furotin P21 da KRAS ke aiki a ƙasan hanyar siginar EGFR. Da zarar an canza KRAS, har abada yana kunna siginar ƙasa, yana mai da hanyoyin kwantar da hankali na EGFR mara amfani kuma yana haifar da ci gaba da yaɗuwar ƙwayoyin cuta. Sakamakon haka, maye gurbin KRAS yana da alaƙa da juriya ga masu hana EGFR tyrosine kinase inhibitors a cikin ciwon huhu da kuma maganin rigakafin EGFR a cikin ciwon daji mai launi.

A cikin 2008, National Comprehensive Cancer Network (NCCN) ta kafa jagororin asibiti suna ba da shawarar gwajin maye gurbin KRAS ga duk masu fama da ciwon daji na metastatic (mCRC) kafin magani. Sharuɗɗan sun nuna cewa yawancin kunna maye gurbi na KRAS yana faruwa a cikin codons 12 da 13 na exon 2. Don haka, saurin gano maye gurbin KRAS mai sauri da daidai yana da mahimmanci don jagorantar ingantaccen maganin asibiti.

Me yasa Gwajin KRAS Yayi Mahimmanci a cikiMetastaticCmai yawaCancer(mCRC)

Ciwon daji mai launi (CRC) ba cuta ɗaya ba ce amma tarin nau'ikan ƙananan ƙwayoyin cuta. Maye gurbi na KRAS-wanda ke cikin kusan kashi 40-45% na marasa lafiya na CRC-suna aiki azaman “akan kunnawa” akai-akai, yana haɓaka haɓakar ciwon daji ba tare da siginar waje ba. Ga marasa lafiya tare da mCRC, matsayin KRAS yana ƙayyade ingancin anti-EGFR monoclonal antibodies kamar Cetuximab da Panitumumab:

Nau'in daji KRAS:Wataƙila majiyyata za su amfana daga maganin anti-EGFR.

Mutant KRAS:Marasa lafiya ba su sami fa'ida daga waɗannan wakilai ba, suna yin haɗarin illar da ba dole ba, ƙarin farashi, da jinkiri a cikin ingantaccen magani.

Daidaitaccen gwaji na KRAS don haka shine ginshiƙin tsara jiyya na keɓaɓɓen.

Kalubalen Ganewa: Ware siginar maye gurbi

Hanyoyi na al'ada sau da yawa ba su da hankali don ƙananan maye gurbi, musamman a cikin samfuran da ke da ƙananan ƙwayar ƙwayar cuta ko bayan ƙaddamarwa. Wahalhalun ya ta'allaka ne wajen bambance siginar DNA mai rauni a kan wani babban nau'in daji-kamar gano allura a cikin hay. Sakamakon da ba daidai ba zai iya haifar da rashin fahimta game da jiyya da rashin daidaituwa.

Maganinmu: Ingantacciyar Injiniya don Amintaccen Gane maye gurbi

Kit ɗin Gano Mutuwar KRAS ɗin mu yana haɗa fasahar ci gaba don shawo kan waɗannan iyakoki, yana ba da daidaito na musamman da amincin jagorar jiyya na mCRC.

Yadda Fasahar Mu Ke Tabbatar da Babban Aiki

• Haɓaka fasahar ARMS (Amplification Refractory Mutation System): Gina kan fasahar ARMS, haɗa fasahar haɓaka mallakar mallaka don ƙara ƙayyadaddun ganowa.
• Enzymatic Enrichment: Yana amfani da ƙuntatawa endonucleases don narkar da mafi yawan kwayoyin halittar ɗan adam ta asali na daji, keɓance nau'ikan mutant, don haka haɓaka ƙudurin ganowa da rage ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun bayanai saboda babban asalin genome.
• Kashe Yanayin Zazzabi: Yana gabatar da takamaiman matakan zafin jiki a cikin tsarin PCR, yana haifar da rashin daidaituwa tsakanin madaidaicin madaidaicin madauri da samfuran nau'in daji, ta haka rage asalin nau'in daji da haɓaka ƙudurin ganowa.
• Babban Hankali: Gano daidai daidai ƙasa da 1% mutant DNA.
• Kyakkyawan Daidaito: Yana amfani da ma'auni na ciki da UNG enzyme don hana sakamako mai kyau na ƙarya da mara kyau.
• Sauƙaƙa kuma Mai Sauƙi: Yana kammala gwaji a cikin kusan mintuna 120, yana amfani da bututun amsawa guda biyu don sauƙaƙe gano maye gurbi guda takwas, samar da haƙiƙa da ingantaccen sakamako.
• Daidaituwar Kayan Aiki: Yana daidaitawa da kayan aikin PCR daban-daban.

Madaidaicin magani a cikin ciwon daji na launin fata yana farawa da ainihin binciken kwayoyin halitta. Ta hanyar ɗaukar Kit ɗin Gano Mutation na KRAS, dakin gwaje-gwajenku na iya ba da tabbataccen sakamako, sakamako masu aiki waɗanda ke siffata hanyar magani kai tsaye.

Ƙaddamar da ɗakin binciken ku tare da ingantaccen, fasaha mai yanke hukunci-kuma ba da damar kulawa da keɓaɓɓen gaske.

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Ƙara koyo game da haɗa wannan ci-gaba bayani a cikin aikin bincike na ku.

#Colorectal #Cancer #DNA #Mutation #Precision #Maganin #Maganin #Cancer

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