Sauye-sauyen maki a cikin kwayar halittar KRAS suna da alaƙa da nau'ikan ciwon daji na ɗan adam, tare da yawan maye gurbi na kusan 17%-25% a cikin nau'ikan ciwon daji, 15%-30% a cikin ciwon daji na huhu, da 20%-50% a cikin ciwon daji na hanji. Waɗannan maye gurbi suna haifar da juriya ga magani da ci gaban ciwon daji ta hanyar wata hanya mai mahimmanci: furotin P21 da KRAS ya tsara yana aiki a ƙasan hanyar siginar EGFR. Da zarar an canza KRAS, yana ci gaba da kunna siginar ƙasa, yana sa magungunan da aka yi niyya a sama da EGFR ba su da tasiri kuma yana haifar da ci gaba da yaduwar ƙwayoyin cuta masu cutarwa. Sakamakon haka, maye gurbi na KRAS yana da alaƙa da juriya ga masu hana EGFR tyrosine kinase a cikin ciwon daji na huhu da kuma maganin rigakafi na anti-EGFR a cikin ciwon daji na hanji.

A shekara ta 2008, Cibiyar Kula da Ciwon Daji ta Kasa (NCCN) ta kafa jagororin asibiti da ke ba da shawarar gwajin maye gurbin KRAS ga duk marasa lafiya da ke fama da ciwon daji na hanji (mCRC) kafin a yi musu magani. Jagororin sun nuna cewa yawancin maye gurbin KRAS yana faruwa ne a cikin codons 12 da 13 na exon 2. Don haka, gano maye gurbin KRAS cikin sauri da daidaito yana da mahimmanci don jagorantar maganin asibiti mai dacewa.

Me yasa Gwajin KRAS yake da mahimmanci a cikinMrashin ƙarfiCruwan idoCancer(mCRC)

Ciwon daji na hanji (CRC) ba cuta ɗaya ba ce amma tarin ƙananan nau'ikan ƙwayoyin halitta daban-daban. Sauye-sauyen KRAS—wanda ke cikin kusan kashi 40–45% na marasa lafiya na CRC—suna aiki a matsayin canjin “kunnawa” akai-akai, suna haɓaka haɓakar ciwon daji ba tare da la'akari da siginar waje ba. Ga marasa lafiya da ke da mCRC, matsayin KRAS yana ƙayyade ingancin ƙwayoyin rigakafi na monoclonal anti-EGFR kamar Cetuximab da Panitumumab:

KRAS Nau'in Daji:Marasa lafiya za su iya amfana daga maganin hana EGFR.

KRAS mai canzawa:Marasa lafiya ba sa samun wata fa'ida daga waɗannan magungunan, suna fuskantar haɗarin illolin da ba dole ba, ƙaruwar farashi, da jinkiri wajen ingantaccen magani.

Saboda haka, gwajin KRAS mai inganci da kuma mai sauƙin fahimta shine ginshiƙin tsarin kula da lafiya na musamman.

Kalubalen Ganowa: Ware Siginar Canjin Halittu

Hanyoyin gargajiya galibi ba su da sauƙin ganewa game da sauye-sauyen da ba su da yawa, musamman a cikin samfuran da ke da ƙarancin adadin ƙari ko bayan cire sinadarin calcium. Wahalar tana cikin bambance-bambancen siginar DNA mai rauni da asalin daji mai girma - kamar neman allura a cikin tarin ciyawa. Sakamakon da ba daidai ba na iya haifar da maganin da ba a sani ba da kuma sakamako mai lalacewa.

Maganinmu: An ƙera shi daidai gwargwado don gano sauye-sauyen da ke da alaƙa da aminci

Kayan Gano Muhalli na KRAS ɗinmu yana haɗa fasahohin zamani don shawo kan waɗannan ƙuntatawa, yana ba da daidaito da aminci na musamman ga jagorar maganin mCRC.

Yadda Fasaharmu Ta Tabbatar da Ingantaccen Aiki

• Ingantaccen fasahar ARMS (Tsarin Canza Ƙarfin Ƙarfafawa): Yana ginawa akan fasahar ARMS, yana haɗa da fasahar haɓaka kayan aiki don ƙara takamaiman ganowa.
• Ingantaccen Tsarin Enzymatic: Yana amfani da ƙwayoyin cuta masu hana ƙwayoyin cuta don narke yawancin asalin halittar ɗan adam, yana adana nau'ikan ƙwayoyin cuta masu maye gurbi, don haka yana haɓaka ƙudurin ganowa da rage yawan ƙwayoyin cuta marasa takamaiman saboda babban tushen kwayoyin halitta.
• Toshewar Zafin Jiki: Yana gabatar da takamaiman matakan zafin jiki a cikin tsarin PCR, yana haifar da rashin daidaito tsakanin firam ɗin maye gurbi da samfuran nau'in daji, ta haka yana rage asalin nau'in daji da inganta ƙudurin ganowa.
• Babban Jin Daɗi: Yana gano ƙarancin kashi 1% na DNA mai canzawa.
• Daidaito Mai Kyau: Yana amfani da ƙa'idodin ciki da kuma enzyme na UNG don hana sakamako mara kyau da mara kyau.
• Mai Sauƙi da Sauri: Yana kammala gwaji cikin kimanin mintuna 120, yana amfani da bututun amsawa guda biyu don sauƙaƙe gano sauye-sauye guda takwas daban-daban, yana samar da sakamako mai kyau da inganci.
• Dacewar Kayan Aiki: Yana dacewa da kayan aikin PCR daban-daban.

Maganin da ya dace a cikin ciwon daji na hanji yana farawa da ingantaccen ganewar ƙwayoyin halitta. Ta hanyar amfani da Kayan Gano Canjin Muhalli na KRAS, dakin gwaje-gwajenku zai iya samar da sakamako masu inganci, waɗanda za a iya aiwatarwa kai tsaye waɗanda ke tsara hanyar magani ga majiyyaci.

Ƙarfafa dakin gwajin ku da ingantaccen fasaha mai inganci—kuma ku ba da damar kulawa ta musamman.

Tuntube mu: marketing@mmtest.Com

Ƙara koyo game da haɗa wannan mafita mai ci gaba cikin tsarin aikin binciken ku.

#Launuka #Ciwon daji #DNA #Murabba'i #Daidaitawa #An Yi Niyya #Magani #Ciwon daji

Buɗe Maganin Daidaito a Ciwon Daji na Canjin Hanci

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