Maganin Tsaro na Aspirin

Aspirin, a matsayin magani mai mahimmanci na maganin ƙwayar cuta, ana amfani dashi sosai a cikin rigakafi da kuma magance cututtuka na zuciya da jijiyoyin jini da kuma cututtuka na cerebrovascular.Binciken ya gano cewa an gano wasu marasa lafiya da ba za su iya hana aikin platelets ba yadda ya kamata ba duk da amfani da aspirin kadan na dogon lokaci, wato, aspirin resistance (AR). Adadin shine kusan 50% -60%, kuma akwai bambance-bambancen launin fata. Glycoprotein IIb/IIIa (GPI IIb/IIIa) yana taka muhimmiyar rawa a cikin tarawar platelet da thrombosis mai tsanani a wuraren da ke fama da rauni na jijiyoyin jini. Nazarin ya nuna cewa kwayoyin halittar polymorphisms suna taka muhimmiyar rawa a juriya na aspirin, galibi suna mai da hankali kan GPIIa P1A1/A2, PEAR1 da PTGS1 gene polymorphisms. GPIIA P1A2 shine babban kwayar halitta don juriya na aspirin. Maye gurbi a cikin wannan kwayar halitta yana canza tsarin masu karɓar GPIIb/IIIa, yana haifar da haɗin kai tsakanin platelet da tarawar platelet. Binciken ya gano cewa yawan P1A2 alleles a cikin marasa lafiya na aspirin ya fi girma fiye da na marasa lafiya na aspirin, kuma marasa lafiya tare da P1A2/A2 maye gurbi na homozygous ba su da tasiri sosai bayan shan aspirin. Marasa lafiya tare da mutant P1A2 alleles da ke jurewa stenting suna da adadin abubuwan aukuwar thrombotic na subacute wanda ya ninka na P1A1 na nau'in daji na homozygous sau biyar, yana buƙatar ƙarin allurai na aspirin don cimma tasirin anticoagulant. PEAR1 GG allele yana amsawa da kyau ga aspirin, kuma marasa lafiya tare da AA ko AG genotype waɗanda suke ɗaukar aspirin (ko hade da clopidogrel) bayan dasa stent suna da babban ciwon zuciya da mace-mace. PTGS1 GG genotype yana da babban haɗari na juriya na aspirin (HR: 10) da kuma yawan abubuwan da ke faruwa na zuciya da jijiyoyin jini (HR: 2.55). Genotype AG yana da matsakaicin haɗari, kuma ya kamata a kula da hankali sosai ga tasirin maganin aspirin. Halin AA genotype ya fi kulawa da aspirin, kuma abubuwan da ke faruwa na cututtukan zuciya suna da ƙananan ƙananan. Sakamakon gano wannan samfurin kawai yana wakiltar sakamakon gano ƙwayoyin halittar ɗan adam PEAR1, PTGS1, da GPIIIA.