Maganin Tsaron Aspirin

Aspirin, a matsayin maganin haɗakar platelet mai tasiri, ana amfani da shi sosai wajen rigakafi da magance cututtukan zuciya da jijiyoyin jini. Binciken ya gano cewa an gano cewa wasu marasa lafiya ba sa iya hana aikin platelet yadda ya kamata duk da amfani da aspirin na dogon lokaci mai ƙarancin yawa, wato juriyar aspirin (AR). Yawansa ya kai kusan kashi 50%-60%, kuma akwai bambance-bambancen launin fata a bayyane. Glycoprotein IIb/IIIa (GPI IIb/IIIa) yana taka muhimmiyar rawa a cikin haɗakar platelet da thrombosis mai tsanani a wuraren da jijiyoyin jini suka ji rauni. Nazarin ya nuna cewa bambancin kwayoyin halitta yana taka muhimmiyar rawa a cikin juriyar aspirin, galibi yana mai da hankali kan bambancin kwayoyin halitta na GPIIIi P1A1/A2, PEAR1 da PTGS1. GPIIIi P1A2 shine babban kwayar halitta don juriyar aspirin. Sauye-sauye a cikin wannan kwayar halitta yana canza tsarin masu karɓar GPIIb/IIIa, wanda ke haifar da haɗin gwiwa tsakanin platelets da haɗakar platelets. Binciken ya gano cewa yawan ƙwayoyin P1A2 a cikin marasa lafiya da ke jure wa aspirin ya fi na marasa lafiya da ke jure wa aspirin yawa, kuma marasa lafiya da ke da maye gurbi na P1A2/A2 homozygous ba su da tasiri sosai bayan shan aspirin. Marasa lafiya da ke da ƙwayoyin P1A2 masu maye gurbi waɗanda aka yi musu stenting suna da ƙimar thrombotic event wanda ya ninka na marasa lafiya da ke da nau'in P1A1 homozygous wild-type sau biyar, suna buƙatar ƙarin allurai na aspirin don cimma tasirin hana zubar jini. Allele na PEAR1 GG yana amsawa da kyau ga aspirin, kuma marasa lafiya da ke da nau'in AA ko AG waɗanda ke shan aspirin (ko tare da clopidogrel) bayan dasa stent suna da babban bugun zuciya da mace-mace. Genotype na PTGS1 GG yana da babban haɗarin juriya ga aspirin (HR: 10) da kuma yawan faruwar cututtukan zuciya da jijiyoyin jini (HR: 2.55). Genotype na AG yana da matsakaicin haɗari, kuma ya kamata a kula da tasirin maganin aspirin sosai. Genotype na AA ya fi saurin kamuwa da aspirin, kuma yawan aukuwar cututtukan zuciya da jijiyoyin jini yana da ƙasa kaɗan. Sakamakon gano wannan samfurin yana wakiltar sakamakon gano kwayoyin halittar PEAR1, PTGS1, da GPIIIa na ɗan adam ne kawai.