Mutum CYP2C19 Gene Polymorphism

CYP2C19 yana ɗaya daga cikin mahimman ƙwayoyin metabolizing magunguna a cikin dangin CYP450. Mutane da yawa endogenous substrates da kuma game da 2% na asibiti kwayoyi suna metabolized ta CYP2C19, kamar metabolism na antiplatelet tara inhibitors (kamar clopidogrel), proton famfo inhibitors (omeprazole), anticonvulsants, da dai sauransu CYP2C19 gene polymorphisms kuma suna da bambance-bambance a cikin metabolizing ikon da alaka da kwayoyi. Wadannan maye gurbi na * 2 (rs4244285) da * 3 (rs4986893) suna haifar da asarar aikin enzyme da aka sanya ta hanyar CYP2C19 gene da raunin ƙarfin substrate na rayuwa, da kuma ƙara yawan ƙwayar jini, don haifar da mummunan halayen miyagun ƙwayoyi dangane da haɗuwa da jini. * 17 (rs12248560) na iya ƙara yawan aikin enzyme da aka sanya ta hanyar CYP2C19 gene, samar da metabolites masu aiki, da haɓaka hani na tara platelet da ƙara haɗarin zubar jini. Ga mutanen da ke da jinkirin metabolism na kwayoyi, yin amfani da allurai na al'ada na dogon lokaci zai haifar da mummunar guba da sakamako masu illa: yawanci lalacewar hanta, lalacewar tsarin hematopoietic, lalacewar tsarin juyayi na tsakiya, da dai sauransu, wanda zai iya haifar da mutuwa a lokuta masu tsanani. Dangane da bambance-bambancen mutum a cikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (UM, * 17 / * 17, * 1 / * 17), metabolism mai sauri (RM, * 1 / * 1) , matsakaicin matsakaici (IM, * 1 / * 2, * 1 / * 3), jinkirin metabolism (PM, * 2/*2, * 3/* 3, * 3/* 3).