Mutum CYP2C19 Gene Polymorphism

CYP2C19 yana ɗaya daga cikin mahimman ƙwayoyin metabolizing magunguna a cikin dangin CYP450.Mutane da yawa endogenous substrates da kuma game da 2% na asibiti kwayoyi suna metabolized ta CYP2C19, irin su metabolism na antiplatelet tara inhibitors (kamar clopidogrel), proton famfo inhibitors (omeprazole), anticonvulsants, da dai sauransu. kwayoyi masu alaka.Wadannan maye gurbi na * 2 (rs4244285) da * 3 (rs4986893) suna haifar da asarar aikin enzyme da aka sanya ta hanyar CYP2C19 gene da rauni na ikon substrate na rayuwa, kuma yana haɓaka maida hankali na jini, don haifar da mummunan halayen ƙwayoyi masu alaƙa. maida hankali na jini.* 17 (rs12248560) na iya ƙara yawan aikin enzyme da aka sanya ta hanyar CYP2C19 gene, samar da metabolites masu aiki, da haɓaka haɓakar haɓakar platelet da haɓaka haɗarin zub da jini.Ga mutanen da ke da jinkirin metabolism na kwayoyi, yin amfani da allurai na al'ada na dogon lokaci zai haifar da mummunar guba da sakamako masu illa: yawanci lalacewar hanta, lalacewar tsarin hematopoietic, lalacewar tsarin juyayi na tsakiya, da dai sauransu, wanda zai iya haifar da mutuwa a lokuta masu tsanani.Dangane da bambance-bambancen mutum a cikin daidaitaccen ƙwayar ƙwayar ƙwayar cuta, gabaɗaya ya kasu kashi huɗu phenotypes, wato ultra- fast metabolism (UM, * 17/*17, * 1/*17), saurin metabolism (RM, * 1/*1). ) , matsakaicin metabolism (IM, *1/*2, *1/*3), jinkirin metabolism (PM, *2/*2, *2/*3, *3/*3).