Tsarin Halittar Halittar Dan Adam na CYP2C19

CYP2C19 yana ɗaya daga cikin muhimman enzymes masu narkewar magunguna a cikin dangin CYP450. Yawancin substrates na ciki da kusan kashi 2% na magungunan asibiti ana metabolize su ta hanyar CYP2C19, kamar metabolism na antiplatelet aggregation inhibitors (kamar clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, da sauransu. Polymorphisms na kwayoyin halittar CYP2C19 suma suna da bambance-bambance a cikin ikon metabolizing na magunguna masu alaƙa. Waɗannan maye gurbi na maki na *2 (rs4244285) da *3 (rs4986893) suna haifar da asarar aikin enzyme da kwayar halittar CYP2C19 ta ƙunsa da raunin ikon metabolization na substrate, da kuma ƙara yawan jini, don haifar da mummunan halayen magunguna da suka shafi yawan jini. *17 (rs12248560) na iya ƙara yawan aikin enzyme da kwayar halittar CYP2C19 ta ƙunsa, samar da metabolites masu aiki, da kuma haɓaka hana tarin platelets da ƙara haɗarin zubar jini. Ga mutanen da ke fama da jinkirin shan magunguna, shan allurai na yau da kullun na dogon lokaci zai haifar da mummunan guba da illa: galibi lalacewar hanta, lalacewar tsarin hematopoietic, lalacewar tsarin jijiyoyi na tsakiya, da sauransu, wanda zai iya haifar da mutuwa a cikin mawuyacin hali. Dangane da bambance-bambancen mutum ɗaya a cikin metabolism na magunguna masu dacewa, gabaɗaya ana raba shi zuwa nau'ikan halittu guda huɗu, wato metabolism mai sauri (UM,*17/*17,*1/*17), metabolism mai sauri (RM,*1/*1), metabolism mai tsaka-tsaki (IM, *1/*2, *1/*3), metabolism mai jinkirin (PM, *2/*2, *2/*3, *3/*3).