Mutane cyp29 gene polymorphism

Cyp2C19 yana daya daga cikin mahimman magani menzoles a cikin dangin Cyp450. Many endogenous substrates and about 2% of clinical drugs are metabolized by CYP2C19, such as the metabolism of antiplatelet aggregation inhibitors (like clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, etc. CYP2C19 gene polymorphisms also have differences in the metabolizing ability of magunguna masu alaƙa. Wadannan maye gurbi na * 2 (Rs4244285) da * 3 (RS4986893) sa asarar ayyukan enz189) taro na jini. *17 (rs12248560) could increase the enzyme activity encoded by CYP2C19 gene, the production of active metabolites, and enhance the platelet aggregation inhibition and increase the bleeding risk. Ga mutane masu jinkirin metabolism na kwayoyi, ɗaukar allurai na yau da kullun zai haifar da mummunan yanayin yanayin yanayin, da sauransu, wanda ke iya haifar da kisa a lokuta masu tsauri. Dangane da bambance-bambancen mutum a cikin metabolism miyagun ƙwayoyi, an raba shi zuwa cikin phenotypes huɗu, um, * 17 / * 1 / * 1 ), tsaka-tsakin metabolism (im, * 1 / * 2 / * 3), jinkirin metabolism (PM, * 2 / * 2, * 3, * 3 / * 3).