Gano BCR-ABL mai mahimmanci don maganin CML

Ciwon myelogenousleukemia na yau da kullun (CML) cuta ce mai haɗari ta clonal ta ƙwayoyin halittar jini. Fiye da kashi 95% na marasa lafiya na CML suna ɗauke da chromosome Philadelphia (Ph) a cikin ƙwayoyin jininsu. Kuma kwayar halittar haɗin BCR-ABL tana samuwa ne ta hanyar canzawa tsakanin ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) akan dogon hannun chromosome 9 (9q34) da kwayar halittar yanki na breakpoint cluster (BCR) akan dogon hannun chromosome 22 (22q11). Sunadaran haɗinsa da wannan kwayar halitta ta ƙunsa yana da aikin tyrosine kinase (TK), kuma yana kunna hanyoyin siginar sa na ƙasa (kamar RAS, PI3K, da JAK/STAT) don haɓaka rarrabuwar ƙwayoyin halitta da hana apoptosis na ƙwayoyin halitta, yana sa ƙwayoyin halitta su yi yawa cikin haɗari, kuma ta haka ne ke haifar da faruwar CML.

Kwayar halittar haɗin BCR-ABL, wacce take da mahimmanci a cikin ci gaban CML, tana aiki azaman babban alamar ganewar asali na CML. Gano shi yana taimakawa wajen sa ido kan majiyyaci'Amsar da aka bayar ga masu hana tyrosine kinase (TKIs) kuma tana annabta sake dawowar cutar sankarar bargo, wanda yake da mahimmanci ga ingantaccen kula da marasa lafiya na CML.

BCR-ABL na ɗan adamKayan Gano Canjin Halittar Haɗakadaga Macro & Micro-Test don gano BCR-ABL a cikin marasa lafiya na CML ta hanyar inganci, yana taimakawa wajen gano cutar CML kuma yana jagorantar jiyya na asibiti da aka yi niyya don inganta dabarun magani don ingantaccen kulawar marasa lafiya. Tsarin haɗin BCR-ABLe, wandashinemuhimmancia cikin ci gaban CML,yana aiki a matsayin alamar ganewar asali mai mahimmanciofCMLGano shi yana taimakawa wajenna'urar saka idanumai haƙuri'smartani ga masu hana tyrosine kinase (TKIs)kumayana hasashen sake dawowar cutar sankarar bargo, wanda shinemahimmancito mai tasiriCMLkula da marasa lafiya.

Kayan Gano Canjin Halittar Haɗakar BCR-ABL na Ɗan Adam daga Macro & Micro-Test don gano BCR-ABL a cikin marasa lafiya na CML ta hanyar inganci, taimakawaCMLganewar asalikumajagororimagungunan asibiti da aka yi niyyatoingantaedabarun warkewa don ingantaccen tsarin kula da marasa lafiya.

CikakkeDzaɓe:A lokaci gudaganowadon3kwayoyin halittar da aka haɗa (P210, P190, P230)donfaɗaɗa ɗaukar hoto da kumarigakafin kamuwa da cuta da aka rasa;

Babban Jin Daɗi:Sigar ruwa tana gano kwayoyin halittar haɗuwatare da LoDna kwafi 1000/mL,kuma sigar da aka yi wa lyophilizedof Kwafi 500/mL;

Madalla sosaiAdaidaito: Ina cikiikoda kuma enzyme na UNG don hana tasirin ƙarya& korau;

Sauƙin Aiki da Inganci:Aikin bututun rufewa,babu samfurabayan sarrafawa,kumaganowaa cikinMinti 60donsakamako masu inganci da inganci;

KaraZaɓuɓɓuka:Sigar ruwa da ta lyophilized don zaɓuɓɓukan abokan ciniki;

Dacewar Faɗi:Dace da yawancin tsarin PCR don samun damar dakin gwaje-gwaje.