Mutum BCR-ABL Fusion Gene Mutation

Takaitaccen Bayani:

Wannan kit ɗin ya dace don gano ƙimar p190, p210 da p230 isoforms na BCR-ABL fusion gene a cikin samfuran marrow na ɗan adam.


Cikakken Bayani

Tags samfurin

Sunan samfur

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Kit (Fluorescence PCR)

Epidemiology

Myelogenousleukemia na yau da kullun (CML) cuta ce mai muni na clonal na ƙwayoyin sel hematopoietic.Fiye da 95% na marasa lafiya na CML suna ɗauke da chromosome na Philadelphia (Ph) a cikin ƙwayoyin jinin su.Ciwon ƙwayar cuta mafi girma na CML shine kamar haka: Halin haɗin gwiwar BCR-ABL yana samuwa ta hanyar canzawa tsakanin abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) a kan dogon hannu na chromosome 9 (9q34) da kuma yanki mai fashewa ( BCR) gene akan dogon hannu na chromosome 22 (22q11);furotin na fusion wanda aka sanya ta wannan kwayar halitta yana da aikin tyrosine kinase (TK), kuma yana kunna hanyoyin siginar da ke ƙasa (kamar RAS, PI3K, da JAK / STAT) don haɓaka rarrabawar tantanin halitta da hana apoptosis tantanin halitta, yana sa sel suna yaduwa da mummunar cuta, kuma ta haka yana haifar da lalacewa. faruwar CML .BCR-ABL yana ɗaya daga cikin mahimman alamun bincike na CML.Canji mai ƙarfi na matakin kwafin sa alama ce mai dogaro don tsinkayar hukunce-hukuncen cutar sankarar bargo kuma ana iya amfani da ita don hango komowar cutar sankarar bargo bayan jiyya.

Tashoshi

FAM BCR-ABL fusion gene
VIC/HEX Ikon Cikin Gida

Ma'aunin Fasaha

Adana Liquid: ≤-18 ℃ A cikin duhu
Rayuwar rayuwa Ruwa: watanni 9
Nau'in Samfura Samfurin marrow na kashi
LoD 1000 Kwafi/ml

Musamman

 

Babu wani giciye-reactivity tare da sauran fusion genes TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, da PML-RARa
Abubuwan da ake Aiwatar da su Abubuwan da aka Aiwatar da Biosystems 7500 Tsarin PCR na Gaskiya

Abubuwan da aka Aiwatar da Tsarin Halittu 7500 Tsarin PCR Mai Saurin Real-Time

QuantStudio® 5 Tsarin PCR na Gaskiya

SLAN-96P Tsarin PCR na Gaskiya

LightCycler®480 Tsarin PCR na Gaskiya

LineGene 9600 Plus Tsarin Gane PCR na Gaskiya

MA-6000 Mai ƙididdige yawan zafin jiki na ainihi

BioRad CFX96 Tsarin PCR na Gaskiya

BioRad CFX Opus 96 Tsarin PCR na Gaskiya


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