Mutum ROS1 Fusion Gene Mutation

ROS1 shine transmembrane tyrosine kinase na dangin mai karɓar insulin.ROS1 fusion gene an tabbatar da shi azaman wani muhimmin kwayar cutar ciwon huhu mara ƙarami.A matsayin wakilin sabon nau'in nau'in kwayoyin halitta na musamman, abubuwan da suka faru na ROS1 fusion gene a NSCLC Kimanin 1% zuwa 2% ROS1 galibi yana jure tsarin sake fasalin kwayoyin halitta a cikin exons 32, 34, 35 da 36. Bayan an hade shi da kwayoyin halitta irin su CD74, EZR, SLC34A2, da SDC4, zai ci gaba da kunna yankin ROS1 tyrosine kinase.ROS1 kinase da aka kunna ba daidai ba zai iya kunna hanyoyin sigina na ƙasa kamar RAS/MAPK/ERK, PI3K/Akt/mTOR, da JAK3/STAT3, don haka suna shiga cikin haɓakawa, bambance-bambance da metastasis na ƙwayoyin tumor, da haifar da ciwon daji.Daga cikin maye gurbi na ROS1, CD74-ROS1 yana da kusan kashi 42%, EZR na kusan kashi 15%, SLC34A2 yana da kusan kashi 12%, SDC4 yana da kusan kashi 7%.Nazarin ya nuna cewa wurin daurin ATP na yankin catalytic na ROS1 kinase da kuma ATP-binding site na ALK kinase suna da homology na har zuwa 77%, don haka ALK tyrosine kinase ƙananan ƙwayoyin ƙwayoyin cuta crizotinib da sauransu suna da tasirin warkewa a fili. a cikin maganin NSCLC tare da maye gurbi na ROS1.Saboda haka, gano ROS1 fusion maye gurbi shine jigo da tushe don jagorantar amfani da magungunan crizotinib.