Mutum EGFR Gene 29 Maye gurbi

Takaitaccen Bayani:

Ana amfani da wannan kit ɗin don gano ainihin maye gurbi na yau da kullun a cikin exons 18-21 na kwayar EGFR a cikin samfura daga marasa lafiyar huhu marasa ƙanƙanta.


Cikakken Bayani

Tags samfurin

Sunan samfur

HWTS-TM001A-Human EGFR Gene 29 Kit ɗin Gane Maɓalli (Fluorescence PCR)

Epidemiology

Ciwon daji na huhu ya zama babban sanadin mutuwar cutar kansa a duniya, yana yin barazana ga lafiyar ɗan adam.Ciwon daji na huhun da ba ƙaramin cell ya kai kusan kashi 80 cikin ɗari na masu ciwon huhu ba.EGFR a halin yanzu shine mafi mahimmancin manufa ta kwayoyin halitta don maganin ciwon daji na huhu mara karami.phosphorylation na EGFR na iya inganta haɓakar ƙwayar ƙwayar cuta, bambance-bambance, mamayewa, metastasis, anti-apoptosis, da haɓaka angiogenesis na ƙari.EGFR tyrosine kinase inhibitors (TKI) na iya toshe hanyar siginar EGFR ta hanyar hana EGFR autophosphorylation, ta haka ne ya hana haɓakawa da bambance-bambancen ƙwayoyin ƙwayar cuta, haɓaka apoptosis cell tumor, rage ƙwayar angiogenesis, da dai sauransu, don cimma nasarar maganin da aka yi niyya.Yawancin karatu sun nuna cewa tasirin maganin warkewa na EGFR-TKI yana da alaƙa da alaƙa da matsayin maye gurbi na EGFR, kuma yana iya hana haɓakar ƙwayoyin ƙwayar cuta musamman tare da maye gurbin EGFR.Halin EGFR yana kan guntun hannu na chromosome 7 (7p12), tare da cikakken tsawon 200Kb kuma ya ƙunshi 28 exons.Yankin da aka canza ya fi girma a cikin exon 18 zuwa 21, codons 746 zuwa 753 maye gurbi akan exon 19 yana da kusan kashi 45% kuma maye gurbin L858R akan exon 21 yana da kusan 40% zuwa 45%.Ka'idojin NCCN don Bincike da Magance Ciwon Kankara mara Karan Huhu ya bayyana a sarari cewa ana buƙatar gwajin maye gurbin EGFR kafin gudanar da EGFR-TKI.Ana amfani da wannan kit ɗin gwajin don jagorantar gudanarwar magungunan haɓakar haɓakar epidermal tyrosine kinase inhibitor (EGFR-TKI), da kuma samar da tushen maganin keɓaɓɓen magani ga marasa lafiya da ciwon huhu mara ƙanƙara.Ana amfani da wannan kit ɗin ne kawai don gano sauye-sauye na yau da kullun a cikin kwayar halittar EGFR a cikin marasa lafiya da ciwon huhu mara ƙanƙanta.Sakamakon gwajin don nunin asibiti ne kawai kuma bai kamata a yi amfani da shi a matsayin tushen kawai don maganin keɓantaccen mutum na marasa lafiya ba.Ya kamata likitoci suyi la'akari da yanayin majiyyaci, alamun ƙwayoyi, da magani Ana amfani da amsawa da sauran alamun gwajin gwaje-gwaje da wasu dalilai don yanke hukunci ga sakamakon gwajin.

Tashoshi

FAM IC Reaction Buffer, L858R Reaction Buffer, 19del Reaction Buffer, T790M Reaction Buffer, G719X Reaction Buffer, 3Ins20 Reaction Buffer, L861Q Reaction Buffer, S768I Reaction Buffer

Ma'aunin Fasaha

Adana Liquid: ≤-18 ℃ A cikin duhu;Lyophilized: ≤30 ℃ A cikin duhu
Rayuwar rayuwa Ruwa: watanni 9;Lyophilized: watanni 12
Nau'in Samfura sabon ƙwayar ƙwayar ƙwayar cuta, sashin daskararrun ƙwayoyin cuta, ƙwayar cuta mai ƙwayar cuta ko sashin paraffin, plasma ko jini
CV 5.0%
LoD Gano maganin maganin nucleic acid a ƙarƙashin bangon nau'in daji na 3ng/μL, na iya gano ƙimar maye gurbin 1% daidai.
Musamman Babu wani giciye-reactivity tare da nau'in halittar halittar DNA na ɗan adam da sauran nau'ikan mutant
Abubuwan da ake Aiwatar da su Abubuwan da aka Aiwatar da Biosystems 7500 Tsarin PCR na GaskiyaAbubuwan da aka Aiwatar da Biosystems 7300 Tsarin PCR na Gaskiya

QuantStudio® 5 Tsarin PCR na Gaskiya

LightCycler® 480 Tsarin PCR na Gaskiya

BioRad CFX96 Tsarin PCR na Gaskiya

Gudun Aiki

5a96c5434dc358f19d21fe9888959493


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