Mutum BCR-ABL Fusion Gene Mutation
Sunan samfur
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Kit (Fluorescence PCR)
HWTS-GE016A-Daskare-bushewar ɗan Adam BCR-ABL Fusion Gane Gane Halitta (Fluorescence PCR)
Epidemiology
Myelogenousleukemia na yau da kullun (CML) cuta ce mai muni na clonal na ƙwayoyin sel hematopoietic. Fiye da 95% na marasa lafiya na CML suna ɗauke da chromosome na Philadelphia (Ph) a cikin ƙwayoyin jinin su. Mafi mahimmancin cututtuka na CML shine kamar haka: Halin haɗin gwiwar BCR-ABL yana samuwa ta hanyar canzawa tsakanin abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) a kan dogon hannu na chromosome 9 (9q34) da yanki na yanki (BCR) a kan dogon hannu na chromosome 12 (q12); furotin fusion wanda aka sanya ta wannan kwayar halitta yana da aikin tyrosine kinase (TK), kuma yana kunna hanyoyin siginar da ke ƙasa (kamar RAS, PI3K, da JAK / STAT) don inganta rarrabawar kwayar halitta da kuma hana apoptosis tantanin halitta, yana sa kwayoyin halitta suyi mummunan rauni, kuma ta haka ne ya haifar da abin da ya faru na CML. BCR-ABL yana ɗaya daga cikin mahimman alamun bincike na CML. Canji mai ƙarfi na matakin kwafin sa alama ce mai dogaro don tsinkayar hukunce-hukuncen cutar sankarar bargo kuma ana iya amfani da ita don hango komowar cutar sankarar bargo bayan jiyya.
Tashoshi
| FAM | BCR-ABL fusion gene |
| VIC/HEX | Ikon Cikin Gida |
Ma'aunin Fasaha
| Adana | Liquid: ≤-18 ℃ A cikin duhu |
| Rayuwar rayuwa | Ruwa: watanni 9 |
| Nau'in Samfura | Samfurin marrow na kashi |
| LoD | 1000 Kwafi/ml |
| Musamman
| Babu wani giciye-reactivity tare da sauran fusion genes TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, da PML-RARa |
| Abubuwan da ake Aiwatar da su | Abubuwan da aka Aiwatar da Biosystems 7500 Tsarin PCR na Gaskiya Abubuwan da aka Aiwatar da Tsarin Halittu 7500 Tsarin PCR Mai Saurin Real-Time QuantStudio® 5 Tsarin PCR na Gaskiya SLAN-96P Tsarin PCR na Gaskiya LightCycler®480 Tsarin PCR na Gaskiya LineGene 9600 Plus Tsarin Gane PCR na Gaskiya MA-6000 Mai ƙididdige yawan zafin jiki na ainihi BioRad CFX96 Tsarin PCR na Gaskiya BioRad CFX Opus 96 Tsarin PCR na Gaskiya |
