Canjin Halittar Haɗakar BCR-ABL ta Ɗan Adam

Ciwon myelogenousleukemia na yau da kullun (CML) cuta ce mai haɗari ta clonal ta ƙwayoyin halittar jini. Fiye da kashi 95% na marasa lafiya na CML suna ɗauke da chromosome Philadelphia (Ph) a cikin ƙwayoyin jininsu. Babban sanadin CML shine kamar haka: Ana samar da kwayar halittar BCR-ABL ta hanyar canzawa tsakanin abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) akan dogon hannun chromosome 9 (9q34) da kwayar halittar yanki mai fashewa (BCR) akan dogon hannun chromosome 22 (22q11); furotin ɗin haɗin da wannan kwayar halitta ta ƙunsa yana da aikin tyrosine kinase (TK), kuma yana kunna hanyoyin siginar sa na ƙasa (kamar RAS, PI3K, da JAK/STAT) don haɓaka rarrabuwar ƙwayoyin halitta da hana apoptosis na ƙwayoyin halitta, yana sa ƙwayoyin halitta su yi yawa cikin haɗari, kuma ta haka ne ke haifar da faruwar CML. BCR-ABL yana ɗaya daga cikin mahimman alamun gano cutar CML. Canjin yanayin da ake ciki a matakin tantancewar cutar sankarar bargo wata alama ce mai inganci ta gano cutar sankarar bargo kuma ana iya amfani da ita wajen hasashen sake dawowar cutar sankarar bargo bayan an yi mata magani.