Mutum BCR-ABL Fusion Gene Mutation
Sunan samfur
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Kit (Fluorescence PCR)
Epidemiology
Myelogenousleukemia na yau da kullun (CML) cuta ce mai muni na clonal na ƙwayoyin sel hematopoietic.Fiye da 95% na marasa lafiya na CML suna ɗauke da chromosome na Philadelphia (Ph) a cikin ƙwayoyin jinin su.Ciwon ƙwayar cuta mafi girma na CML shine kamar haka: Halin haɗin gwiwar BCR-ABL yana samuwa ta hanyar canzawa tsakanin abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) a kan dogon hannu na chromosome 9 (9q34) da kuma yanki mai fashewa ( BCR) gene akan dogon hannu na chromosome 22 (22q11);furotin na fusion wanda aka sanya ta wannan kwayar halitta yana da aikin tyrosine kinase (TK), kuma yana kunna hanyoyin siginar da ke ƙasa (kamar RAS, PI3K, da JAK / STAT) don haɓaka rarrabawar tantanin halitta da hana apoptosis tantanin halitta, yana sa sel suna yaduwa da mummunar cuta, kuma ta haka yana haifar da lalacewa. faruwar CML .BCR-ABL yana ɗaya daga cikin mahimman alamun bincike na CML.Canji mai ƙarfi na matakin kwafin sa alama ce mai dogaro don tsinkayar hukunce-hukuncen cutar sankarar bargo kuma ana iya amfani da ita don hango komowar cutar sankarar bargo bayan jiyya.
Tashoshi
| FAM | BCR-ABL fusion gene |
| VIC/HEX | Ikon Cikin Gida |
Ma'aunin Fasaha
| Adana | Liquid: ≤-18 ℃ A cikin duhu |
| Rayuwar rayuwa | Ruwa: watanni 9 |
| Nau'in Samfura | Samfurin marrow na kashi |
| LoD | 1000 Kwafi/ml |
| Musamman
| Babu wani giciye-reactivity tare da sauran fusion genes TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, da PML-RARa |
| Abubuwan da ake Aiwatar da su | Abubuwan da aka Aiwatar da Biosystems 7500 Tsarin PCR na Gaskiya Abubuwan da aka Aiwatar da Tsarin Halittu 7500 Tsarin PCR Mai Saurin Real-Time QuantStudio® 5 Tsarin PCR na Gaskiya SLAN-96P Tsarin PCR na Gaskiya LightCycler®480 Tsarin PCR na Gaskiya LineGene 9600 Plus Tsarin Gane PCR na Gaskiya MA-6000 Mai ƙididdige yawan zafin jiki na ainihi BioRad CFX96 Tsarin PCR na Gaskiya BioRad CFX Opus 96 Tsarin PCR na Gaskiya |
