Dan adam bcr-abl maon Geneuya

Cutar classogenogenousleama (cml) cuta ce ta CLONEL ta cutar hematopoetic sel. Fiye da 95% na marasa lafiya na CML suna ɗaukar Philadelphia Chromosome (pH) a cikin sel sel. Pathogenants na cml kamar haka: An kafa Gene na BCR-Ablis ta hanyar wucewa tsakanin Chromoogen orcoogen 9) a kan dogon hannu na chromosome 9 (9q34) da kuma backopoint na cruster ( BCR) Gene a hannu mai tsayi na chromosome 22 (22q11); Aikin Fusien An kafa shi da wannan Gashin yana da aikin Tyrosine, kuma yana kunna hanyoyin rarraba sel kuma yana haifar da ras, apoptosel authoptosis, don haka yana haifar da sel abin da ya faru na cml. BCR-ABL shine ɗayan mahimman alamomin bincike na cml. Canjin da aka gabatar na matakin rubutun ta amintaccen mai nuna alama ga hukuncin cutar sankara kuma ana iya amfani da shi don hangosa nazarin cutar sankarar bargo bayan jiyya.