Sauye-sauyen Halittar Dan Adam ta EGFR 29

Ciwon daji na huhu ya zama babban abin da ke haifar da mace-macen ciwon daji a duk duniya, wanda hakan ke barazana ga lafiyar ɗan adam. Ciwon daji na huhu wanda ba ƙaramin ƙwayar halitta ba ne ke da alhakin kusan kashi 80% na marasa lafiya da ke fama da ciwon daji na huhu. EGFR a halin yanzu shine mafi mahimmancin abin da ake nufi da maganin ciwon daji na huhu wanda ba ƙaramin ƙwayar halitta ba ne. Phosphorylation na EGFR na iya haɓaka haɓakar ƙwayoyin cuta, bambance-bambance, mamayewa, metastasis, anti-apoptosis, da haɓaka angiogenesis na ƙari. Masu hana EGFR tyrosine kinase (TKI) na iya toshe hanyar siginar EGFR ta hanyar hana haɓakar EGFR autophosphorylation, ta haka yana hana yaduwa da bambance-bambancen ƙwayoyin cuta, haɓaka apoptosis na ƙwayoyin cuta, rage angiogenesis na ƙari, da sauransu, don cimma maganin da aka yi niyya ga ƙari. Yawancin bincike sun nuna cewa ingancin maganin EGFR-TKI yana da alaƙa da matsayin maye gurbin kwayar halittar EGFR, kuma yana iya hana haɓakar ƙwayoyin cuta tare da maye gurbin kwayar halittar EGFR. Kwayar halittar EGFR tana kan ɗan gajeren hannun chromosome 7 (7p12), tare da cikakken tsawon 200Kb kuma ta ƙunshi exons 28. Yankin da aka canza yana da yawa a cikin exons 18 zuwa 21, maye gurbin share codons 746 zuwa 753 akan exon 19 yana da kusan kashi 45% kuma maye gurbin L858R akan exon 21 yana da kusan kashi 40% zuwa 45%. Jagororin NCCN don Gano da Maganin Ciwon Huhu Mara Ƙaramin Kwayar Halitta ya bayyana a sarari cewa ana buƙatar gwajin maye gurbin kwayar halittar EGFR kafin a fara amfani da EGFR-TKI. Ana amfani da wannan kayan gwajin don jagorantar gudanar da magungunan epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), kuma yana samar da tushen magani na musamman ga marasa lafiya da ciwon huhu mara ƙaramin ƙwayar halitta. Ana amfani da wannan kayan aikin ne kawai don gano maye gurbi gama gari a cikin kwayar halittar EGFR a cikin marasa lafiya da ciwon huhu mara ƙaramin ƙwayar halitta. Sakamakon gwajin don amfani ne kawai na asibiti kuma bai kamata a yi amfani da shi azaman tushen magani na musamman ga marasa lafiya ba. Ya kamata likitocin asibiti su yi la'akari da yanayin majiyyaci, alamun magani, da magani. Ana amfani da martani da sauran alamun gwajin dakin gwaje-gwaje da sauran abubuwan don yin hukunci dalla-dalla kan sakamakon gwajin.