KRAS 8 Maye gurbi

An sami maye gurbin maki a cikin kwayar halittar KRAS a cikin nau'ikan nau'ikan ƙwayar cuta na ɗan adam, kusan 17% ~ 25% maye gurbi a cikin ƙari, 15% ~ 30% maye gurbi a cikin marasa lafiya na huhu, 20% ~ 50% maye gurbi a cikin marasa lafiya na launin fata. Saboda furotin na P21 da K-ras gene ke ƙullawa yana ƙarƙashin hanyar siginar EGFR, bayan maye gurbin halittar K-ras, hanyar siginar siginar koyaushe tana aiki kuma ba ta tasiri ta sama da magungunan da aka yi niyya akan EGFR, wanda ke haifar da ci gaba da yaɗuwar ƙwayoyin cuta. Maye gurbi a cikin kwayar halittar K-ras gabaɗaya yana ba da juriya ga masu hana EGFR tyrosine kinase a cikin masu cutar kansar huhu da juriya ga magungunan rigakafin EGFR a cikin masu cutar kansar launi. A cikin 2008, National Comprehensive Cancer Network (NCCN) ta ba da ƙa'idar aikin asibiti game da ciwon daji na colorectal, wanda ya nuna cewa wuraren maye gurbi da ke haifar da kunna K-ras galibi suna cikin codons 12 da 13 na exon 2, kuma sun ba da shawarar cewa duk marasa lafiya da ke da ci gaban ciwon daji na metastatic na launin toka kafin a iya gwada maganin mutation na K-ras. Don haka, saurin gano ainihin ƙwayoyin halittar K-ras yana da mahimmanci a cikin jagorar magunguna na asibiti. Wannan kit ɗin yana amfani da DNA a matsayin samfurin ganowa don samar da ƙima na ƙima na matsayin maye gurbi, wanda zai iya taimakawa likitocin a tantance cutar kansar launin fata, ciwon huhu da sauran masu ciwon daji waɗanda ke amfana da magungunan da aka yi niyya. Sakamakon gwajin kit ɗin don nunin asibiti ne kawai kuma bai kamata a yi amfani da shi a matsayin kawai tushen jiyya na daidaikun marasa lafiya ba. Ya kamata ma'aikatan asibiti su yi cikakkun hukunce-hukunce kan sakamakon gwajin bisa dalilai kamar yanayin majiyyaci, alamun magunguna, amsawar jiyya da sauran alamun gwajin gwaji.